Metformin: A Candidate Drug for Renal Diseases

Drug Dose Adjustment in Chronic Renal Diseases

The development of numerous drugs over the last two decades to a variety of diseases with significant benefits has paralleled increasing awareness of the adverse effects of these drugs. Majority of the drugs are eliminated by the kidneys. Therefore it is mandatory to make appropriate dosage modification when renal function deteriorates to prevent drug toxicity. Dosage modification tables of lar...

Metformin and renal injury protection

Implication for health policy/practice/research/medical education: Metformin protects against tubular injury by modulation of oxidative stress on the tubules and restoring the biochemical alterations. While in diabetes, glycosuria causes tubular cell injury. Furthermore metformin is able to protect podocytes in diabetic nephropathy. These findings may suggest the clinical use of metformin in th...

Metformin: A possible drug for treatment of endometrial cancer

Metformin is a widely used first-line drug for treatment of type 2 diabetes mellitus. In recent years, it has been reported that administration of metformin can reduce carcinogenic risk and inhibit proliferation of cancer cells including those from glioma and breast cancer. The underlying mechanism is thought to involve increased LKB-1 phosphorylation induced by metformin, followed by LKB-1 pho...

Diseases of the urinary system. Drug-induced renal disorders: I.

Density Functional Theory Calculations of Functionalized Carbon Nanotubes with Metformin as Vehicles for Drug Delivery

Drug delivery by nanomaterials is an active emergent research area and CNTs draws considerable potential application owing to its unique quasi one-dimensional structure and electronic properties. Single walled carbon nanotubes and carbon fullerenes can be used in drug delivery due to their mechanical and chemical stability. The past few years, increasing attention by several reputed groups has ...